decision support for vaccine efficacy trial design during an emerging outbreak
The design and execution of rigorous, fast, and ethical vaccine efficacy trials can be challenging during epidemics of emerging diseases. Response to an urgent public health crisis requires accelerated research even as emerging epidemics themselves evolve rapidly and inherently are less well understood. The InterVax Tool is an online visual, interactive tool developed to help diverse stakeholders navigate the various epidemiological, logistical and ethical decisions involved in the design of a vaccine efficacy trial during emerging epidemics.
The tool is not intended to provide a black box decision tree for identifying an optimal trial design, but rather a means of facilitating a transparent, collaborative and comprehensive discussion of the relevant decisions and for recording the decision process.
Users can get started with the Video Tutorial (linked above) and can also explore pre-annotated scenarios on the 2014-2016 West African Ebola Epidemic and the 2016 Zika Epidemic in the Americas (linked at bottom).